The present study was designed to investigate the effect of Allium sativum (Liliaceae) bulb extract on early stage diabetic cardiomyopathy in alloxan-induced diabetic rats. Diabetes was induced in wistar rats by injecting single dose administration of alloxan (150 mg/kg, i.p.). In the present study 35 rats were divided into 7 groups, each group containing 5 rats; non-diabetic group, diabetic group and A. sativum extract treated group. Each extract was administered orally at the dose of 100 mg/kg to the diabetic rats daily for 14 days. Fasting blood glucose (FBG), total cholesterol (TC), creatine kinase (CK) and lactate dehydrogenase (LDH) were determined by standard methods. Administration of different A. sativum extracts i.e. ethanol (EASE), chloroform (CASE), aceton (AASE) and aqueous (AqASE) were found to decrease the level of FBG, TC, CK and LDH as compared to diabetic control group. AqASE was found to decrease the LDH and CK level more significantly as compared to other extracts. Histopathological studies revealed salvage in the morphological dearrangements as indicated by decrease in necrotic lesions, perivascular oedema and inflammatory cells in A. sativum extracts treated group as compared to diabetic control. The present study conclude that administration of AqASE attenuate the severity and improves the myocardium functioning in alloxan induced DCM more significantly as compared to other extracts.
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